The Amoebal MAP Kinase Response to Legionella pneumophila Is Regulated by DupA
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چکیده
منابع مشابه
The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA.
The amoeba Dictyostelium discoideum can support replication of Legionella pneumophila. Here we identify the dupA gene, encoding a putative tyrosine kinase/dual-specificity phosphatase, in a screen for D. discoideum mutants altered in allowing L. pneumophila intracellular replication. Inactivation of dupA resulted in depressed L. pneumophila growth and sustained hyperphosphorylation of the amoeb...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2009
ISSN: 1931-3128
DOI: 10.1016/j.chom.2009.08.005